Home

Research

1

Treatment of mercuric chloride poisoning with dimercaptosuccinic acid and diuretics: preliminary studies.

Aaseth J, Alexander J, Raknerud N.
J Toxicol Clin Toxicol 1982;19:173-186.
2

Treatment of methyl mercury poisoning in mice with 2,3- dimercaptosuccinic acid and other complexing thiols.

Aaseth J, Friedheim EA.
Acta Pharmacol Toxicol 1978;42:248-
3

The effect of dental amalgam restorations on blood mercury levels.

Abraham JE, Svare CW, Frank CW.
J Dent Res 1984;63:71-73.
4

Urinary excretion of meso-2,3- dimercaptosuccinic acid in human subjects.

Aposhian HV, Maiorino RM, Dart RC, Perry DF.
Clin Pharmacol Ther 1989;45:520-526.
5

Human studies with the chelating agents, DMPS and DMSA.

Aposhian HV, Maiorino RM, Rivera M, et al.
J Toxicol Clin Toxicol 1992;30:505-528.
6

DMSA and DMPS - Watersoluble antidotes for heavy metal poisoning.

Aposhian HV.
Ann Rev Pharmacol Toxicol 1983;23:193-215.
7

Biliary secretion of glutathione-metal complexes.

Ballatori N, Clarkson TW.
Fundam Appl Toxicol 1985;5:816-831.
8

Dependence of biliary secretion of inorganic mercury on the biliary transport of glutathione.

Ballatori N, Clarkson TW.
Biochem Pharmacol 1984;33:1093-1098.
9

Lead poisoning in children.

Berlin CM Jr.
Curr Opin Pediatr 1997 Apr;9(2):173-7.
10

Mercury in saliva and feces after removal of amalgam fillings.

Bjorkman L, Sandborgh-Englund G, Ekstrand J.
Toxicol Appl Pharmacol 1997;144:156-162.
11

Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali workers. Part I: History, neurophysical findings and chelator effects.

Bluhm RE, Bobbitt RG, Welch LG, et al.
Hum Exp Toxicol 1992;11:201-210.
12

Accumulation and removal of Hg203 in different regions of the rat brain.

Butterworth RF, Gonce M, Barbeau A.
Can J Neurol Sci 1978;5:397-400.
13

Persistent effect of in utero meso-2,3-dimercaptosuccinic acid (DMSA) on immune function and leadinduced immunotoxicity.

Chen S, et al.
Toxicology 1999 Jan 1;132(1):67-79.
14

Metal toxicity in the central nervous system.

Clarkson TW.
Environ Health Perspect 1987;75:59-64.
15

Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy.

Cory-Slechta DA, Weiss B, Cox C.
J Pharmacol Exp Ther 1987;243:804-813.
16

Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy.

Cory-Slechta DA.
J Pharmacol Exp Ther 1988 Jul;246(1):84-91.
17

Mercury vapor from dental amalgams, an in vitro study.

Derand T.
Swed Dent J 1989;13:169-175.
18

Toxicological aspects on the release and systemic uptake of mercury from dental amalgam.

Ekstrand J, Bjorkman L, Edlund C, Sandborgh-Englund G.
Eur J Oral Sci 1998;106:678-686.
19

In vivo indices of oxidative stress in leadexposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine.

Ercal N, Treeratphan P, Hammond TC, et al.
Free Radic Biol Med 1996;21:157-161.
20

Combined therapeutic potential of meso-2,3- dimercaptosuccinic acid and calcium disodium edetate on the mobilization of lead in experimental lead intoxication in rats.

Flora SJ, Bhattacharya R, Vijayaraghavan R.
Fundam Appl Toxicol 1995;25:233-240.
21

2,3- Dimercaptosuccinic acid treatment of heavy metal poisoning in humans.

Fournier L, Thomas G, Garnier R, et al.
Med Toxicol Adverse Drug Exp 1988;3:499-504.
22

Mercury poisoning and its potential impact on hormone regulation and aging: preliminary clinical observations using a new therapeutic approach.

Frackelton JP, Christensen RL.
J Adv Med 1998;11:9-25.
23

Mesodimercaptosuccinic acid, a chelating agent for the treatment of mercury poisoning.

Friedheim E, Corvi C.
J Pharm Pharmacol 1975;27:624-626.
24

Chelated lead in relation to lead in bone and ALAD genotype.

Gerhardsson L, et al.
Environ Res 1999 May; 80(4):389-98.
25

Aggressive approach in the treatment of acute lead encephalopathy with an extraordinarily high concentration of lead.

Gordon RA.
Arch Pediatr Adolesc Med 1998 Nov;152(11):1100-4.
26

Placebo response in environmental disease. Chelation therapy of patients with symptoms attributed to amalgam fillings.

Grandjean P, Guldager B, Larsen IB, et al.
J Occup Environ Med 1997;39:707-714.
27

Controlled study of meso-2, 3-dimercaptosuccinic acid for the management of childhood lead intoxication.

Graziano JH, et al.
J Pediatr 1992; 120:133-9.
28

Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.

Graziano JH, et al.
J Pediatr 1988; 113:751-7.
29

Role of 2,3-dimercaptosuccinic acid in the treatment of heavy metal poisoning.

Graziano JH, et al.
Med Toxicol 1986; 1:155-62.
30

2,3- dimercaptosuccinic acid as an antidote for lead intoxication.

Graziano JH, Siris ES, Lolacono N, et al.
Clin Pharmacol Ther 1985;37:432-438.
31

Disposition of metals in rats: a comparative study of fecal, urinary, and biliary excretion and tissue distribution of eighteen metals.

Gregus Z, Klaassen CD.
Toxicol Appl Pharmacol 1986;85:24-38.
32

Role of glutathione and hepatic glutathione S-transferase in the biliary excretion of methyl mercury, cadmium and zinc: a study with enzyme inducers and glutathione depletors.

Gregus Z, Varga F.
Acta Pharmacol Toxicol 1985;56:398-403.
33

[Selected biochemical indicators of the effect of environmental lead on humans].

Ignacak J, Brandys J, Danek M, Moniczewski A.
Folia Med Cracov 1991;32:111-118. [Article in Polish].
34

Biliary and urinary excretion of metals in humans.

Ishihara N, Matsushiro T.
Arch Environ Health 1986;41:324-330.
35

Dental amalgam and mercury.

Jokstad A, Thomassen Y, Bye E, et al.
Pharmacol Toxicol 1992;70:308-313.
36

Mercury excretion and occupational exposure of dental personnel.

Jokstad A.
Community Dent Oral Epidemiol 1990;18:143-148.
37

Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.

Jones MM, Basinger MA, Gale GR, et al.
Toxicology 1994;89:91-100.
38

Effect of chelation treatment with dimercaptosuccinic acid (DMSA) on lead-related blood pressure changes.

Khalil-Manesh F.
Environ Res 1994 Apr;65(1):86-99.
39

Exposure of children to heavy metals from smelters: epidemiology and toxic consequences.

Landrigan PJ, Baker EL.
Environ Res 1981;25:204-224.
40

Provocative chelation with DMSA and EDTA: evidence for differential access to lead storage sites.

Lee BK, et al.
Occup Environ Med 1995 Jan;52(1):13-9.
41

2,3- Dimercaptosuccinic acid in human arsenic poisoning.

Lenz K, Hruby K, Druml W, et al.
Arch Toxicol 1981;47:241-243.
42

The effect of 2,3-dimercaptosuccinic acid in the treatment of lead poisoning in adults.

Lifshitz M, et al.
Ann Med 1997 Feb;29(1):83-5.
43

Mercury exposure from "silver" tooth fillings:emerging evidence questions a traditional dental paradigm.

Lorscheider FL, Murray JV, Summers AO.
FASEB J 1995;9:504-508.
44

[Study on the significance of mercury accumulation in the brain from dental amalgam fillings through direct mouth-nose-brain transport].

Maas C, Bruck W, Haffner HT, Schweinsberg F.
Zentralbl Hyg Umweltmed 1996;198:275-291. [Article in German]
45

Arsenic excretion after treatment of arsenic poisoning with DMSA or DMPS in mice.

Maehashi H and Murata Y.
Jpn J Pharmacol 1986 Jan;40(1):188-90.
46

Determination and metabolism of dithiol chelating agents: X. In humans, meso-2,3- dimercaptosuccinic acid is bound to plasma proteins via mixed disulfide formation.

Maiorino RM, Akins JM, Blaha K, et al.
J Pharmacol Exp Ther 1990;254:570-577.
47

Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3- dimercaptosuccinic acid with L-cysteine in human urine.

Maiorino RM, Bruce DC, Aposhian HV.
Toxicol Appl Pharmacol 1989;97:338-349.
48

Antidotal effects of 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2,3- dimercaptosuccinic acid (DMSA) on the organotoxicity of dibutyltin dichloride (DBTC) in rats.

Merkord J, et al.
Hum Exp Toxicol 2000 Feb;19(2):132-7.
49

Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity.

Miller A.
Altern Med Rev 1998; 3:199-207.
50

Are we ready to replace dimercaprol (BAL) as an arsenic antidote?

Muckter H, Liebl B, Reichl FX, et al.
Hum Exp Toxicol 1997;16:460-465.
51

Effect of four thiolcontaining chelators on the disposition of orally administered mercuric chloride.

Nielson JB, Andersen O.
Hum Exp Toxicol 1991;10:423-430.
52

Mercury in dental practice. II. Urinary mercury excretion in dental personnel.

Nilsson B.
Swed Dent J 1986;10:221-232.
53

Lead and the kidney: nephropathy, hypertension, and gout.

Perazella MA.
Conn Med 1996;60:521-526.
54

The influence of chelating agents on the distribution and biotransformation of methylmercuric chloride in rats.

Planas-Bohne F.
J Pharmacol Exp Ther 1981;217:500-504.
55

The use of chelating agents in occupational lead poisoning.

Porru S and Alessio L.
Occup Med (Lond) 1996 Feb;46(1):41-8.
56

Use of orally administered succimer (meso- 2,3-dimercaptosuccinic acid) for treatment of lead poisoning in dogs.

Ramsey DT, Casteel SW, Faggella AM, et al.
J Am Vet Med Assoc 1996;208:371-375.
57

Urinary excretion of mercury after occupational exposure to mercury vapour and influence of the chelating agent meso-2,3- dimercaptosuccinic acid (DMSA).

Roels HA, Boeckx M, Ceulemans E, Lauwerys RR.
Br J Ind Med 1991 Apr;48(4):247-53.
58

Effects of meso-2,3-dimercaptosuccinic acid (DMSA) on methyl mercury-induced teratogenesis in mice.

Sanchez DJ, et al.
Ecotoxicol Environ Saf 1993 Aug;26(1):33-9.
59

Mercury in biological fluids after amalgam removal.

Sandborgh-Englund G, Elinder CG, Langworth S, et al.
J Dent Res 1998;77:615-624.
60

Risk estimation of mercury intake from different sources.

Schweinsberg F.
Toxicol Lett 1994;72:345-351.
61

The contribution of dental amalgam to mercury in blood.

Snapp KR, Boyer DB, Peterson LC, Svare CW.
J Dent Res 1989;68:780-785.
62

The effect of dental amalgams on mercury levels in expired air.

Svare C, Peterson L, Reinhardt J, et al.
J Dent Res 1981;60:1668-1671.
63

Therapeutic efficacy of dimercaptosuccinic acid and thiamine/ ascorbic acid on lead intoxication in rats.

Tandon SK, Floras SJS.
Bull Environ Contam Toxicol 1989;43:705-712.
64

Efficacy of combined chelation in lead intoxication.

Tandon SK, Singh S, Jain VK.
Chem Res Toxicol 1994;7:585-589.
65

Methylmercury in populations eating large quantities of marine fish.

Turner MD, Marsh DO, Smith JC, et al.
Arch Environ Health 1980;35:367-377.
66

Intra-oral air mercury released from dental amalgam.

Vimy MJ, Lorscheider FL.
J Dent Res 1985;64:1069-1071.
67

Biological monitoring of mercury vapour exposure by scalp hair analysis in comparison to blood and urine.

Wilhelm M, Muller F, Idel H.
Toxicol Lett 1996;88:221-226.
68

Update on Mercury Mobilization.

Wilson MD, John.
The Great Lakes College of Clinical Medicine International Conference, February 25-27,2000, Atlanta, GA.
69

Neurobehavioral aspects of lead neurotoxicity in children.

Winneke G, Kramer U.
Cent Eur J Public Health 1997;5:65-69.